| Catalog#: |
MK1219H |
| Product Name: |
Recombinant Human CLDN18.2 Protein, hFc Chimera |
| Description: |
Claudin-18 is a protein that in humans is encoded by the CLDN18 gene. CLDN18 belongs to the large claudin family of proteins, which form tight junction strands in epithelial cells. The expression of isoform A2 (CLDN18.2) is restricted to the stomach mucosa where it is predominantly observed in the epithelial cells of the pit region and the base of the gastric glands including exocrine and endocrine cells (at protein level). CLDN18.2 is founded to be abundant in gastric tumors, Experimental antibody IMAB362 targets Claudin 18.2 to help treat gastric cancers. |
| Source: |
HEK293 cells |
| Species: |
Human |
| Tag: |
Fc |
| Formulation: |
Supplied as a solution in 20 mM PB, 500 mM NaCl, 10% glycerol, 0.025% DDM, 0.005% CHS, pH 7.0. |
| Protein length: |
Full length: Met1-Val261 |
| Purity: |
≥ 75% as determined by SDS-PAGE. |
| Storage: |
Store under sterile conditions at -20 °C to -80 °C. Avoid repeated freeze-thaw cycles. |
| Reconstitution: |
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water. |
| Molecular Mass: |
~30 kDa |
| Stability: |
Upon receiving, this product remains stable for 6 months at lower than -70 °C. |
| Endotoxin: |
≤ 0.2 EU/μg of protein by gel clotting method. |
| Notes: |
Research Use Only. Not for use in clinical procedures. |
