| Product Name: |
Recombinant Human CD7, His-Avi-tagged |
| Catalog#: |
MK1034H |
| Species: |
Human |
| Source: |
HEK293 |
| Tag: |
His-Avi |
| Product Overview: |
Recombinant Human CD7 (P09564) (Ala26-Pro180), fused with a C-terminal His-Avi tag, was expressed in HEK293 cells. |
| Description: |
CD7, also known as Leu-9, is an approximately 40 kDa transmembrane protein that functions as a key co-stimulatory molecule on T cells and NK cells. Upon engagement by its ligand, SECTM1, it enhances the activation, proliferation, and integrin-mediated adhesion of these lymphocytes. CD7 is expressed on a range of cells including T cells, NK cells, and various progenitor cells, with its expression level on CD8+ T cells distinguishing naive/memory (CD7-bright) from effector (CD7-dim) populations. Beyond its co-stimulatory role, CD7 is also involved in Galectin-1-induced T cell apoptosis and facilitates the fusion of HIV-1 with target cells. |
| Formulation: |
Formulated in 0.22μm-filtered Phosphate-Buffered Saline (pH 7.4). |
| Purity: |
> 95% as determined by SDS-PAGE. |
| Storage: |
Store under sterile conditions at -20°C to -80°C. Avoid repeated freeze-thaw cycles. |
| Reconstitution: |
Use distilled water to dissolve the protein to a concentration above 100 μg/mL. Aliquot the solution into single-use vials and freeze. |
| Molecular Mass: |
Approximately 19.3 kDa. |
| Stability: |
Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. |
| Endotoxin: |
Less than 1.0 EU per μg as determined by the LAL method. |
| Notes: |
Research Use Only. Not for use in clinical procedures. Aoid repeated freeze-thaw cycles. |
