| Product Name: |
Recombinant Human CD5 (Arg25-Asn371), hFc-Avi-tagged |
| Catalog#: |
MK1033H |
| Species: |
Human |
| Source: |
HEK293 |
| Tag: |
hFc-Avi |
| Product Overview: |
Recombinant Human CD5 (P06127) (Arg25-Asn371) fused with a C-terminal hFc-Avi tag, was expressed in HEK293 cells. |
| Description: |
CD5 (also known as Leu-1) is a 67 kDa transmembrane glycoprotein that functions as a key inhibitory receptor on both T and B lymphocytes. Its primary role is to negatively regulate antigen receptor signaling (both TCR and BCR), which in turn promotes cell survival and maintains immune tolerance and anergy. On T cells, CD5 signaling dampens activation and influences differentiation by promoting Th17 cells while inhibiting regulatory T cells. Similarly, on specific B cell subsets, it supports tolerance and non-responsiveness. Additionally, CD5 is involved in pathogen interactions, as it can bind to fungal components and is utilized by the Hepatitis C virus for cellular entry into T cells. |
| Formulation: |
Formulated in 0.22μm-filtered Phosphate-Buffered Saline (pH 7.4). |
| Purity: |
> 95% as determined by SDS-PAGE. |
| Storage: |
Store under sterile conditions at -20°C to -80°C. Avoid repeated freeze-thaw cycles. |
| Reconstitution: |
Use distilled water to dissolve the protein to a concentration above 100 μg/mL. Aliquot the solution into single-use vials and freeze. |
| Molecular Mass: |
Approximately 67.1 kDa. |
| Stability: |
Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. |
| Endotoxin: |
Less than 1.0 EU per μg as determined by the LAL method. |
| Notes: |
Research Use Only. Not for use in clinical procedures. Aoid repeated freeze-thaw cycles. |
