| Catalog#: |
MK1182H |
| Product Name: |
Recombinant Human CD30 Protein, hFc Chimera |
| Description: |
CD30, also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor family, which regulates proliferation/apoptosis and antibody responses. CD30 is expressed by activated, but not by resting, T and B cells. Aberrant expression of CD30 by mastocytosis mast cells and interaction with its ligand CD30L (CD153) appears to play an important role in the pathogenesis and clinical presentation of systemic mastocytosis. CD30 has been considered as a specific diagnostic biomarker of anaplastic large cell lymphoma (ALCL) and classical Hodgkin lymphoma (cHL). CD30 is also a biomarker used for targeted therapy by an antibody–drug conjugate. |
| Source: |
Human cells |
| Species: |
Human |
| Tag: |
Fc |
| Protein length: |
Phe19-Lys379 |
| Purity: |
≥ 95% as determined by SDS-PAGE. |
| Storage: |
Store under sterile conditions at -20 °C to -80 °C. Avoid repeated freeze-thaw cycles. |
| Reconstitution: |
It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in distilled water up to 100 μg/mL. |
| Molecular Mass: |
90-120 kDa, on SDS-PAGE under reducing conditions. |
| Stability: |
Upon receiving, the product remains stable for 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. |
| Endotoxin: |
≤ 1 EU/μg of protein by LAL method. |
| Notes: |
Research Use Only. Not for use in clinical procedures. |
