| Product Name: |
Recombinant Human CD30, His-Avi-tagged |
| Catalog#: |
MK1026H |
| Species: |
Human |
| Source: |
HEK293 |
| Tag: |
His-Avi |
| Product Overview: |
Recombinant Human CD30/TNFRSF8 protein (P28908-1) (Phe19-Lys379), fused with a C-terminal His-Avi tag, was expressed in HEK293 cells. |
| Description: |
CD30 (TNFRSF8/Ki-1) is a 120 kDa Type I transmembrane glycoprotein belonging to the TNF receptor superfamily. While normally expressed on antigen-stimulated T and B cells, its expression is significantly upregulated in Hodgkin’s disease, other lymphomas, chronic inflammation, and autoimmune diseases, making it a key clinical marker. Functionally, CD30 binds to its ligand (CD30L) to costimulate T cell proliferation, promote a Th2-biased immune response, and induce apoptosis during thymic negative selection. |
| Formulation: |
Lyophilized from a 0.22μm-filtered PBS (pH 7.4) solution containing 5% trehalose as a protectant. |
| Purity: |
> 95% as determined by SDS-PAGE. |
| Storage: |
Store under sterile conditions at -20°C to -80°C. Avoid repeated freeze-thaw cycles. |
| Reconstitution: |
Use distilled water to dissolve the protein to a concentration above 100 μg/mL. Aliquot the solution into single-use vials and freeze. |
| Molecular Mass: |
The protein has a predicted MW of 41.3 kDa. |
| Stability: |
Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. |
| Endotoxin: |
Less than 1.0 EU per μg as determined by the LAL method. |
| Notes: |
Research Use Only. Not for use in clinical procedures. Aoid repeated freeze-thaw cycles. |
