| Catalog#: |
MK1167H |
| Product Name: |
Recombinant Human CA125/MUC16 Protein, His-tagged |
| Description: |
MUC16, also known as the CA125 antigen, is a mucin protein that may be found in type I transmembrane or secreted forms that are used monitor the progress of epithelial ovarian cancer therapy. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Binding to MSLN mediates heterotypic cell adhesion. This may contribute to the metastasis of ovarian cancer to the peritoneum by initiating cell attachment to the mesothelial epithelium via binding to MSLN. |
| Source: |
HEK293 cells |
| Species: |
Human |
| Tag: |
His |
| Formulation: |
Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). |
| Protein length: |
Asp12783-Ser13467 |
| Purity: |
> 95% as determined by Bis-Tris PAGE.
> 95% as determined by HPLC. |
| Storage: |
Store under sterile conditions at -20 °C to -80 °C. Avoid repeated freeze-thaw cycles. |
| Reconstitution: |
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water. |
| Molecular Mass: |
76.17 kDa |
| Stability: |
Upon receiving, the product remains stable for 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. |
| Endotoxin: |
Less than 1 EU per μg by the LAL method. |
| Notes: |
Research Use Only. Not for use in clinical procedures. |
